Enabling European archaeological research: The ARIADNE E-infrastructure

Research e-infrastructures, digital archives and data services have become important pillars of scientific enterprise that in recent decades has become ever more collaborative, distributed and data-intensive. The archaeological research community has been an early adopter of digital tools for data acquisition, organisation, analysis and presentation of research results of individual projects. However, the provision of einfrastructure and services for data sharing, discovery, access and re-use has lagged behind. This situation is being addressed by ARIADNE: the Advanced Research Infrastructure for Archaeological Dataset Networking in Europe. This EUfunded network has developed an einfrastructure that enables data providers to register and provide access to their resources (datasets, collections) through the ARIADNE data portal, facilitating discovery, access and other services across the integrated resources. This article describes the current landscape of data repositories and services for archaeologists in Europe, and the issues that make interoperability between them difficult to realise. The results of the ARIADNE surveys on users' expectations and requirements are also presented. The main section of the article describes the architecture of the einfrastructure, core services (data registration, discovery and access) and various other extant or experimental services. The ongoing evaluation of the data integration and services is also discussed. Finally, the article summarises lessons learned, and outlines the prospects for the wider engagement of the archaeological research community in sharing data through ARIADNE

Populating Narratives Using Wikidata Events: An Initial Experiment

The study presented in this paper is part of our research aimed at improving the search functionalities of current Digital Libraries using formal narratives. Narratives are intended as sequences of events. We present the results of an initial experiment to detect and extract implicit events from the Wikidata knowledge base in order to construct a narrative in a semi-automatic way. Wikidata contains many historical entities, but comparably few events. The reason is that most events in Wikidata are represented in an implicit way, e.g. by listing a date of birth instead of having an event of type “birth”. For this reason, we decided to generate what we call the Wikidata Event Graph (WEG), i.e. the graph of implicit events found in Wikidata. We performed an initial experiment taking as case study the narrative of the life of Italian poet Dante Alighieri. Only one event of the life of Dante is explicitly represented in Wikidata as instance of the class Q1190554 Occurrence. Using the WEG, we were able to automatically detect 31 more events of Dante’s life that were present in Wikidata in an implicit way.</p

Foveal avascular zone area and parafoveal vessel density measurements in different stages of diabetic retinopathy by optical coherence tomography angiography

AIM: To investigate foveal avascular zone (FAZ) and parafoveal vessel densities (PRVD) by means of optical coherence tomography angiography (OCTA) in diabetic patients with or without diabetic retinopathy (DR) and to assess the reproducibility of FAZ and PRVD measurements. METHODS: Sixty diabetic patients (60 eyes) with different stage of DR (graded according to the International Clinical Severity Scale for DR) and 20 healthy subjects underwent FAZ area and PRVD measurements using OCTA by two experienced examiners. FAZ area in all patients was also assessed using fluorescein angiography (FA). RESULTS: In subject with proliferative DR and with moderate-severe non proliferative DR, FAZ area was significantly increased compared to healthy controls (P=0.025 and P=0.050 respectively measured with OCTA and P=0.025 and P=0.048 respectively measured with FA). OCTA showed significantly less inter-observer variability compared to FA. Concordance correlation coefficient (CCC) for FAZ area measurements was 0.829 (95%CI: 0.736-0.891) P<0.001 with FA and 1.000 (95%CI: 0.999-1.000) P<0.001 with OCTA. CCC was 0.834 (95%CI: 0.746-0.893) P<0.001 and 0.890 (95%CI: 0.828-0.930) P<0.001 for parafoveal superficial and deep vessel density measurements, respectively. CONCLUSION: OCTA shows progressive increase of FAZ area and reduction of PRVD in both superficial and deep plexus at increasing DR severity. FAZ area and PRVD measurements using OCTA are highly reproducible

Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment

Rationale: Obstructive sleep apnea (OSA) is commonly associated with neurocognitive impairments that have not been consistently related to specific brain structure abnormalities. Knowledge of the brain structures involved in OSA and the corresponding functional implications could provide clues to the pathogenesis of cognitive impairment and its reversibility in this disorder. Objectives: To investigate the cognitive deficits and the corresponding brain morphology changes in OSA, and the modifications after treatment, using combined neuropsychologic testing and voxelbased morphometry. Methods: A total of 17 patients treatment-naive to sleep apnea and 15 age-matched healthy control subjects underwent a sleep study, cognitive tests, and magnetic resonance imaging. After 3 months of treatment, cognitive and imaging data were collected to assess therapy efficacy. Measurements and Main Results: Neuropsychologic results in pretreatment OSA showed impairments in most cognitive areas, and in mood and sleepiness. These impairments were associated with focal reductions of gray-matter volume in the left hippocampus (entorhinal cortex), left posterior parietal cortex, and right superior frontal gyrus. After treatment, we observed significant improvements involving memory, attention, and executive-functioning that paralleled gray-matter volume increases in hippocampal and frontal structures. Conclusions: The cognitive and structural deficits in OSA may be secondary to sleep deprivation and repetitive nocturnal intermittent hypoxemia. These negative effects may be recovered by consistent and thorough treatment. Our findings highlight the importance of early diagnosis and successful treatment of this disorder

Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precursor protein: role of the low-density lipoprotein receptor-related protein.

The Alzheimer's beta-amyloid peptides derive from the proteolytic processing of the beta-amyloid precursor protein, APP, by beta- and gamma-secretases. The regulation of this processing is not fully understood. Experimental evidence suggests that the activation of pathways involving protein tyrosine kinases, such as PDGFR and Src, could induce the cleavage of APP and in turn the generation of amyloid peptides. In this paper we addressed the effect of receptor and nonreceptor protein tyrosine kinases on the cleavage of APP and the mechanisms of their action. To this aim, we developed an in vitro system based on the APP-Gal4 fusion protein stably transfected in SHSY5Y neuroblastoma cell line. The cleavage of this molecule, induced by various stimuli, results in the activation of the transcription of the luciferase gene under the control of Gal4 cis-elements. By using this experimental system we demonstrated that, similarly to Src, three tyrosine kinases, TrkA, Ret and EGFR, induced the cleavage of APP-Gal4. We excluded that this effect was mediated by the activation of Ras-MAPK, PI3K-Akt and PLC-gamma pathways. Furthermore, the direct phosphorylation of the APP cytosolic domain does not affect Abeta peptide generation. On the contrary, experiments in cells lacking the LDL-receptor related protein LRP support the hypothesis that the interaction of APP with LRP is required for the induction of APP cleavage by tyrosine kinases

Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment

The paper assesses the effect of obstructive sleep apnea on brain structure and cognitive performance, and the changes after treatment with Continuous Positive Airway Pressure. The main finding is that cognitive impairment is associated with a decrease of grey-matter volume in specific cerebral regions, and that these can be reversed by treatment with an increase of grey-matter volume in specific hippocampal and frontal brain regions. These changes are significantly correlated with the improvement in specific neuropsychological tests (executive-functioning and short-term memory), underlining the importance of early diagnosis and treatment of sleep apnea. Specific neuropsychological measures represent valuable tools for the assessment of therapy success, and can offer the evidence that adherence to treatment can lead not only to clinical, but also to brain-structural, recovery. Objectives: To investigate the cognitive deficits and the corresponding brain morphology changes in OSA, and the modifications after treatment, using combined neuropsychological testing and Voxel-Based-Morphometry. Methods: 17 treatment-naïve sleep apnea patients and 15 age-matched healthy controls. All underwent a sleep study, cognitive tests and magnetic resonance imaging. After threemonths treatment, cognitive and imaging data were collected to assess therapy efficacy. Measurements and Main Results: Neuropsychological results in pre-treatment OSA showed impairments in most cognitive areas, as well as in mood and sleepiness. These impairments were associated with focal reductions of grey-matter volume in the left hippocampus (enthorinal cortex), left posterior parietal cortex and right superior frontal gyrus. After treatment, we observed significant improvements involving memory, attention and executive-functioning that paralleled grey-matter volume increases in hippocampal and frontal structures. Conclusions: The cognitive and structural deficits in obstructive sleep apnea may be secondary to sleep deprivation and repetitive nocturnal intermittent hypoxemia. These negative effects may be recovered by consistent and throughout treatment. Our findings highlight the importance of early diagnosis and successful treatment of this disorder

Automatic GUI generation for web based information systems

Printed from http://www.isti.cnr.it target=NewWindow>www.isti.cnr.it (March 2005). - On the web page: '2003-10-28'Consiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7 , Rome / CNR - Consiglio Nazionale delle RichercheSIGLEITItal